A good general rule of thumb is that psychoactive chemicals of any kind are a net negative to humans. This includes alcohol, caffeine, tobacco, harder drugs, and even prescription drugs. Our bodies are incredibly finely tuned machines that our best science only understands partially. We do know that eating healthy (vegetables, fruits, seeds, nuts, meats) increases happiness and productivity.
So I would try to eat healthy, reduce and eventually eliminate chemicals like alcohol, caffeine, tobacco, etc.